Review Article

Current State of Modern Biotechnological-Based Aeromonas hydrophila Vaccines for Aquaculture: A Systematic Review

Table 2

Summary of experimented A. hydrophila fish vaccines in terms of antigenic entity used, fish models, route of administration, and reported efficacy.

Antigenic entityModel fish specieRoute of administrationReported efficacyReference

Lipopolysaccharide (LPS) and Outer Membrane
Protein (OMP)
Grass Carp
(Ctenopharyngodon idella)
Injected intraperitoneallyRPS 83.3, 72.2[9]
Recombinant outer membrane protein
R (rOmpR)
Rohu (Labeo rohita)Injected intraperitoneallyRPS 52[6]
Outer membrane protein (Omp-G)eels (Anguilla anguilla)injected intraperitoneallyRPS 50-75[18]
Outer membrane proteins (OmpA1, Tdr, and TbpA)Channel catfish (Ictalurus punctatus)intraperitoneally
(IP) injected
RPS 98.59,
95.59, and 47.89
[7]
Outer Membrane Protein (OMP)Goldfish (Carassius auratusInjected intraperitoneally50%[11]
Outer Membrane Protein (OMP)American
eel (Anguilla rostrata)
Injected intraperitoneallyRPS 50%[21]
Outer membrane protein 48 (Omp48)Rohu (Labeo rohita)intramuscularlyRPS 69[22]
Outer membrane proteins, (Aha1 and OmpW)common carpinjected intraperitoneallyRPS 67 and 80[19]
OmpW PLGARohu (Labeo rohita)orally administeredRPS 37.33- 79.99[26]
Omp38Chinese breamsintraperitoneally immunizedRPS 50.00-57.14[20]
The iron-regulated outer membrane protein (OMP)zebrafish,injected intramuscularlyRPS 63.4-68.6[24]
Live recombinant Lactococcus lactis vaccine expressing
aerolysin genes D1 and D4
Tilapia (Oreochromis niloticus)intraperitoneal injection
oral feeding
RPS 55–82
RPS 70–100
[14]
Recombinant Aeromonas hydrophila vaccine (Aera)grass carpbath immunization-[23]
Recombinant protein aerAGrass carpbath immunization
intramuscular injection
RPS 84.9
RPS 79.6
[17]
N-acyl Homoserine 1 LactonaseZebrafishoral administration-[15]
Fimbrial Proteins (FimA, Fim, FimMrfG, and FimOM)Channel Catfishinjected intraperitoneallyRPS 59.83, 95.41, 85.72, and 75.01[13]
Maltoporin (46 kD)European eel (Anguilla anguilla)intraperitoneal
injected
RPS 62.5-100[12]
Glycoprotein-based native-subunitRainbow
Trout (Oncorhynchus mykiss)
Immersion
injected intraperitoneally
68.0%[10]
Recombinant S-layer protein
vaccine
common carpvaccinated intraperitoneallyRPS 56-87[16]
G-protein coupled receptor 18 (GPR18)channel catfishintraperitoneally injected50-100%[29]
Recombinant Hemolysin Co-regulated Protein (Hcp)Common carp (Cyprinus carpio)injected intraperitoneallyRPS 46.67[25]
DNA vaccine (naked plasmid DNA)grass carpinjected intramuscularlyRPS 68.9[27]
Apolipoprotein A1 plasmid DNAchannel catfishintraperitoneally
injected
100%[28]