Association Study of Myosin Heavy Chain 15 Polymorphisms with Asthma Susceptibility in Chinese Han
Table 3
MYH15 polymorphisms in cases and controls.
SNPs
Case group N
Control group N
Genetic model
OR (95% CI)
P
P
rs12638212 (A>G)
410
418
Add
0.902 (0.721-1.129)
0.367
0.682
AA
149 (0.363)
143 (0.342)
Dom
0.836 (0.598-1.170)
0.297
0.644
AG
187 (0.456)
197 (0.471)
All
1.0589 (0.871-0.287)
0.571
0.874
GG
74 (0.180)
78 (0.187)
Rec
0.925 (0.614-1.395)
0.711
0.938
rs9842751 (T>C)
410
418
Add
0.887 (0.710-1.108)
0.293
0.635
TT
125 (0.305)
122 (0.292)
Dom
0.863 (0.606-1.227)
0.411
0.763
TC
197 (0.480)
198 (0.474)
All
0.936 (0.772-1.136)
0.503
0.874
CC
88 (0.215)
98 (0.234)
Rec
0.839 (0.576-1.224)
0.363
0.642
rs7635009 (A>G)
410
418
Add
0.779 (0.618-0.981)
0.033
0.143
AA
182 (0.444)
160 (0.383)
Dom
0.712 (0.514-0.986)
0.041
0.178
AG
178 (0.434)
198 (0.474)
All
1.197 (0.979-1.463)
0.080
0.347
GG
50 (0.122)
60 (0.144)
Rec
0.731 (0.463-1.155)
0.180
0.642
rs2278980 (C>T)
410
418
Add
0.958 (0.720-1.274)
0.767
0.860
CC
277 (0.676)
276 (0.660)
Dom
0.925 (0.660-1.295)
0.649
0.921
CT
117 (0.285)
131 (0.313)
All
1.009 (0.786-1.295)
0.945
0.955
TT
16 (0.039)
11 (0.026)
Rec
1.119 (0.482-2.598)
0.794
0.938
rs1463431 (C>T)
410
418
Add
1.000 (0.806-1.239)
0.997
0.997
CC
136 (0.332)
135 (0.323)
Dom
1.018 (0.727-1.425)
0.918
0.950
CT
182 (0.444)
194 (0.464)
All
0.994 (0.819-1.207)
0.955
0.955
TT
92 (0.224)
89 (0.213)
Rec
0.976 (0.667-1.428)
0.902
0.948
rs4855559 (G>T)
410
418
Add
1.033 (0.809-1.319)
0.794
0.860
GG
240 (0.585)
238 (0.569)
Dom
0.941 (0.682-1.298)
0.712
0.921
GT
130 (0.317)
148 (0.354)
All
0.987 (0.791-1.231)
0.907
0.955
TT
40 (0.098)
32 (0.077)
Rec
1.455 (0.807-2.624)
0.213
0.642
rs9288876 (T>A)
410
418
Add
0.747 (0.588-0.947)
0.016
0.117
TT
200 (0.488)
176 (0.421)
Dom
0.693 (0.502-0.955)
0.025
0.163
TA
171 (0.417)
191 (0.457)
All
0.808 (0.658-0.993)
0.042
0.347
AA
39 (0.095)
51 (0.122)
Rec
0.669 (0.405-1.103)
0.115
0.642
rs936266 (C>T)
410
418
Add
1. 058 (0.833-1.343)
0.645
0.860
CC
225 (0.549)
228 (0.545)
Dom
0.990 (0.719-1.362)
0.950
0.950
CT
141 (0.344)
156 (0.373)
All
0.267 (0.761-1.172)
0.605
0.874
TT
44 (0.107)
34 (0.081)
Rec
1.379 (0.792-2.399)
0.256
0.642
rs7652606 (A>G)
410
418
Add
0.932 (0.707-1.229)
0.620
0.860
AA
261 (0.637)
253 (0.605)
Dom
0.902 (0.650-1.253)
0.538
0.874
AG
131 (0.320)
148 (0.354)
All
1.088 (0.859-1.378)
0.484
0.874
GG
18 (0.044)
17 (0.041)
Rec
1.026 (0.468-2.250)
0.948
0.948
rs2290600 (A>C)
410
418
Add
1.045 (0.837-1.304)
0.700
0.860
AA
105 (0.256)
106 (0.254)
Dom
1.053 (0.735-1.509)
0.779
0.921
AC
202 (0.493)
210 (0.502)
All
0.991 (0.817-1.201)
0.924
0.955
CC
103 (0.251)
102 (0.244)
Rec
1.068 (0.739-1.544)
0.725
0.938
rs1454197 (T>G)
410
418
Add
0.756 (0.600-0.953)
0.018
0.117
TT
182 (0.444)
157 (0.376)
Dom
0.673 (0.485-0.933)
0.018
0.163
TG
178 (0.434)
201 (0.481)
All
0.823 (0.673-1.006)
0.057
0.347
GG
50 (0.122)
60 (0.144)
Rec
0.731 (0.463-1.155)
0.180
0.642
rs12493483 (A>G)
410
418
Add
1.155 (0.929-1.436)
0.196
0.598
AA
125 (0.305)
130 (0.311)
Dom
1.240 (0.884-1.738)
0.212
0.644
AG
190 (0.463)
206 (0.493)
All
0.919 (0.758-1.116)
0.395
0.874
GG
95 (0.232)
82 (0.196)
Rec
1.188 (0.808-1.747)
0.382
0.642
rs10933946 (T>A)
410
418
Add
1.154 (0.913-1.460)
0.230
0.598
TT
135 (0.329)
149 (0.356)
Dom
1.200 (0.860-1.675)
0.284
0.644
TA
207 (0.505)
202 (0.483)
All
1.070 (0.878-1.302)
0.498
0.874
AA
68 (0.166)
67 (0.160)
Rec
1.213 (0.777-1.893)
0.395
0.642
OR, 95% CI: Odds Ratio, 95% Confidence Interval. N: number of cases and controls. Values are absolute numbers (decimals) and OR, 95% CI. Adjusted for sex, age, body mass index, and smoking history with logistic regression. Corrected by false discovery rate. All: allelic model. Add: additive model; Dom: dominant model; Rec: recessive model. SNPs: single nucleotide polymorphisms.
