Association Study of Myosin Heavy Chain 15 Polymorphisms with Asthma Susceptibility in Chinese Han
Table 4
Haplotype analysis of MYH15 in cases and controls.
Haplotype
Case group N
Control group N
x2
P
OR (95% CI)
A T A C C G T C A A T A T
49.19 (0.060)
53.03 (0.063)
0.078
0.781
0.944 0.629-1.417
A T A C C G T C A A T G A
245.93 (0.300)
235.09 (0.281)
0.925
0.336
1.121 0.888-1.414
A T A C T T T T A C T A A
51.89 (0.063)
53.54 (0.064)
0.002
0.962
0.990 0.664-1.477
G C A T T G T C A C T A T
27.97 (0.034)
18.59 (0.022)
2.195
0.138
1.566 0.861-2.848
G C G C C G A C G A G G T
14.27 (0.017)
25.60 (0.031)
3.076
0.079
0.559 0.290-1.080
G C G C T T A T G C G A T
95.58 (0.117)
102.81 (0.123)
0.151
0.697
0.941 0.694-1.277
G C G T T G A C A C G A T
98.94 (0.121)
108.36 (0.130)
0.295
0.587
0.920 0.682-1.242
others
236.23 (0.288)
238.98 (28.6)
-
-
-
For each haplotype, alleles were arranged in order of rs12638212-rs9842751-rs7635009- rs2278980-rs1463431-rs4855559-rs9288876-rs936266-rs7652606-rs2290600-rs1454197-rs12493483-rs10933946. OR, 95% CI: Odds Ratio, 95% Confidence Interval. N: number of haplotype in case and control group. x2: value tested by Pearson’s Chi-squared test. Adjusted for sex, age, BMI, and smoking history with logistic regression. The lowest frequency threshold (LFT) < 0.03 was pooled in this part.
