Eya2 Is Overexpressed in Human Prostate Cancer and Regulates Docetaxel Sensitivity and Mitochondrial Membrane Potential through AKT/Bcl-2 Signaling
Figure 1
Eya2 expression in prostate cancers. (a) Negative or weak immunostaining of Eya2 in normal prostate tissue. (b) Negative Eya2 staining in prostate cancer. (c) Moderate nuclear Eya2 staining in a prostate cancer. (d) Strong nuclear Eya2 immunostaining in a case of prostate cancer. (e) Analysis of the Singh Prostate dataset of Oncomine. Eya2 mRNA was significantly elevated in prostate cancers compared with normal prostate tissues. (f) Eya2 mRNA in prostate cancers (TCGA). Eya2 mRNA positively correlated with Gleason score. (g) Eya2 mRNA was positively correlated with T stage (TCGA dataset). (h) Eya2 mRNA expression was significantly higher in prostate cancers with nodal metastasis (TCGA dataset). Statistical methods and p values are indicated in the figure.