Research Article
Circulating Angptl3 and Angptl8 Are Increased in Patients with Hypothyroidism
Table 1
Study population information.
| | Group | Healthy control | Subclinical hypothyroidism | Overt hypothyroidism | p value |
| | Sex (F/M) | 29 (16/13) | 30 (23/7) | 29 (24/5) | 0.05 | | Age (year) | 43±11 | 44±13 | 44±15 | 0.43 | | T3 (ng/mL) | 1.30 (1.20-1.41) | 0.95 (0.87-1.02) | 0.89 (0.82-0.97) | <0.001 | | T4 (ug/dL) | 9.78 (1.8-2.76) | 6.61 (6.26-6.97) | 4.13 (3.49-4.77) | <0.001 | | FT3 (pg/mL) | 3.60 (3.33-3.86) | 2.82 (2.64-3.00) | 2.16 (1.98-2.35) | <0.001 | | FT4 (ng/dL) | 1.39 (1.30-1.48) | 1.07 (1.01-1.13) | 0.70 (0.58-0.81) | <0.001 | | TSH (uIU/mL) | 2.46 (1.8-2.76) | 14.19 (10.36-19.07) | 16.48 (9.86-45.17) | <0.01 | | TPOAb (U/mL) | 18.71(15-22.79) | 177.45 (23.26-236.68) | 117.45 (57.69-352.23) | <0.01 | | TgAb (U/mL) | 16.08 (12.18-30.69) | 468.6 (206.2-557.5) | 437.15 (234.13-1326.2) | <0.01 | | Insulin (pmol/L) | 10.44±4.82 | 10.69±7.54 | 11.58±8.77 | >0.05 | | HDL-C (mmol/L) | 1.15 (1.07-1.22) | 1.41 (1.28-1.53) | 1.25 (1.15-1.35) | >0.05 | | LDL-C (mmol/L) | 2.33(1.77-2.59) | 2.58(2.21-2.91) | 2.73 (2.44-3.62) | <0.001 | | TG (mmol/L) | 1.01 (0.83-1.19) | 1.45 (1.16-1.73) | 1.37 (1.08-1.66) | >0.05 | | TC (mmol/L) | 4.00 (3.76-4.24) | 4.58 (4.10-5.06) | 4.87 (4.51-5.24) | <0.05 | | Angptl3 (ng/mL) | 4.94 (4.63-5.26) | 5.36 (5.03-5.69) | 5.49 (5.11-5.88) | <0.05 | | Angptl4 (pg/mL) | 144.80 (116.61–172.99) | 171.21 (138.54–203.89) | 146.89 (122.05–171.73) | >0.05 | | Angptl8 (pmol/L) | 0.63(0.57-0.69) | 0.69 (0.64-0.74) | 0.67(0.61-0.74) | <0.05 |
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F: female; M, male.
a. Data are expressed as mean±SD.
b. Data are expressed as median with interquartile range.
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