Telmisartan Attenuates Uric Acid-Induced Epithelial-Mesenchymal Transition in Renal Tubular Cells

Figure 1

Effects of uric acid on EMT in NRK-52E cells. Cells were treated by different concentrations of UA (100-600 mol/L) for 48 h. (a) mRNA expression of NOX4, E-cadherin, and α-SMA by RT-PCR. (b) Protein expression of NOX4, E-cadherin, and α-SMA by Western blot. Immunofluorescence analysis of E-cadherin (c) and α-SMA protein (d). Magnification, ×200. The results are presented as mean ± SD obtained from three independent experiments. P<0.05; P<0.01. NC, normal control; UA, uric acid.

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