Telmisartan Attenuates Uric Acid-Induced Epithelial-Mesenchymal Transition in Renal Tubular Cells

Figure 2

Role of ET-1 in uric acid-induced EMT in NRK-52E cells. (a) ET-1 production determined by ELISA when exposed to different concentrations of UA. Cells were treated by UA (600 mol/L) with or without ET-1 receptor inhibitor BQ123 (1 mol/L) or BQ788 (1 mol/L). E-cadherin and α-SMA expression were detected by RT-PCR (b) and Western blot (c). The results are presented as mean ± SD obtained from three independent experiments. P<0.05; P<0.01. NC, normal control; UA, uric acid.

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