Telmisartan Attenuates Uric Acid-Induced Epithelial-Mesenchymal Transition in Renal Tubular Cells

Figure 6

Telmisartan inhibited uric acid-induced EMT in NRK-52E cells via inhibiting the NADPH oxidase/ERK1/2/ET-1 pathway. Cells were treated by 600 mol/L UA with or without telmisartan (10² – 10⁴ nmol/L) for 48 h. (a) Level of ROS was measured by DHE staining, Magnification, ×200. (b) Expression of pERK and ERK by Western blot. (c) ET-1 concentration in supernatant by ELISA. The results are presented as mean ± SD obtained from three independent experiments. P<0.05; P<0.01. NC, normal control; UA, uric acid; TE, telmisartan; DHE, dihydroethidium.

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