Peroxynitrite and 4-Hydroxynonenal Inactivate Breast Cancer Resistance Protein/ABCG2

<div>Effect of 4-hydroxynonenal (4HNE) on the transport of riboflavin into<i> Sf9</i>-BCRP/ABCG2 membrane vesicles, expressed as pmol riboflavin/mg protein/min. Data are mean ± SD from 3-4 determinations. (a) BCRP-mediated transport of riboflavin in the presence of 200 <i>μ</i>M of 4HNE (filled circles) vs. control (open symbols); (b) inhibition of riboflavin uptake by 4-hydroxynonenal (4HNE).</div>

BioMed Research International

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Figure 2

Figure 2: Peroxynitrite and 4-Hydroxynonenal Inactivate Breast Cancer Resistance Protein/ABCG2 