Ranking Cancer Proteins by Integrating PPI Network and Protein Expression Profiles

Figure 4

Cancer dependency evidences for the top 20 ranked proteins. The pie charts in (a) and (b) separately represent the percentage of top 20 ranked proteins excluding KDPs and 20 randomly selected candidate proteins, which are necessary for the survival of colon tumor or other cancers.. The gene annotation classes depend on the DS given by Cancer Dependency Map, which consists of colon cancer related proteins (DS<-2; red), other cancers related proteins (DS<-2; yellow), and proteins without relating to cancers or having no information (gray).

(a)

(b)