Research Article
Bioinformatics Analysis Identified Key Molecular Changes in Bladder Cancer Development and Recurrence
Table 1
Gene ontology and KEGG pathway analysis of differentially expressed genes according to method 1.
| | | Category | Term | Count | % | value |
| | GO analysis | GOTERM_CC_DIRECT | GO:0005654∼nucleoplasm | 42 | 28.1879194630872 | 1.22E − 05 | | GOTERM_MF_DIRECT | GO:0005515∼protein binding | 92 | 61.744966442953 | 8.65E − 05 | | GOTERM_BP_DIRECT | GO:0051301∼cell division | 12 | 8.05369127516778 | 1.08E − 04 | | GOTERM_BP_DIRECT | GO:0006260∼DNA replication | 8 | 5.36912751677852 | 2.35E − 04 | | GOTERM_CC_DIRECT | GO:0005737∼cytoplasm | 60 | 40.2684563758389 | 2.68E − 04 | | GOTERM_MF_DIRECT | GO:0019901∼protein kinase binding | 11 | 7.38255033557047 | 7.94E − 04 | | GOTERM_BP_DIRECT | GO:0000082∼G1/S transition of mitotic cell cycle | 6 | 4.02684563758389 | 0.001302766851924 | | GOTERM_CC_DIRECT | GO:0000922∼spindle pole | 6 | 4.02684563758389 | 0.001440410268581 | | GOTERM_MF_DIRECT | GO:0004693∼cyclin-dependent protein serine/threonine kinase activity | 4 | 2.68456375838926 | 0.002393195271174 | | GOTERM_BP_DIRECT | GO:0001706∼endoderm formation | 3 | 2.01342281879194 | 0.003901253353245 | | GOTERM_CC_DIRECT | GO:0005813∼centrosome | 10 | 6.71140939597315 | 0.005184882974603 | | GOTERM_CC_DIRECT | GO:0005739∼mitochondrion | 20 | 13.4228187919463 | 0.005522684005422 | | GOTERM_BP_DIRECT | GO:0051591∼response to cAMP | 4 | 2.68456375838926 | 0.005751402857203 | | GOTERM_BP_DIRECT | GO:0098609∼cell-cell adhesion | 8 | 5.36912751677852 | 0.005854477268833 | | GOTERM_CC_DIRECT | GO:0005829∼cytosol | 38 | 25.5033557046979 | 0.007692882731082 |
| | KEGG pathway | KEGG_PATHWAY | hsa04110: cell cycle | 7 | 4.6979865771812 | 0.00123536590764 | | KEGG_PATHWAY | hsa05222: small cell lung cancer | 5 | 3.35570469798657 | 0.009218413749072 | | KEGG_PATHWAY | hsa04151: PI3K-Akt signaling pathway | 9 | 6.04026845637583 | 0.018153887794995 | | KEGG_PATHWAY | hsa05206: microRNAs in cancer | 8 | 5.36912751677852 | 0.020570720541055 | | KEGG_PATHWAY | hsa04115: p53 signaling pathway | 4 | 2.68456375838926 | 0.02717134771579 | | KEGG_PATHWAY | hsa04920: adipocytokine signaling pathway | 4 | 2.68456375838926 | 0.030418432882382 | | KEGG_PATHWAY | hsa04152: AMPK signaling pathway | 5 | 3.35570469798657 | 0.031444562545736 | | KEGG_PATHWAY | hsa04068: FoxO signaling pathway | 5 | 3.35570469798657 | 0.04111192229316 |
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BP: biological process; CC: cellular component; GO: gene ontology; MF: molecular function.
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