Bioinformatics Analysis Identified Key Molecular Changes in Bladder Cancer Development and Recurrence

Table 2

Gene ontology and KEGG pathway analysis of differentially expressed genes in bladder cancer development and recurrence.

	Bladder cancer development					Bladder cancer recurrence
	Category	Term	Count	%	value	Category	Term	Count	%	value
GO analysis	GOTERM_CC_DIRECT	GO:0070062∼extracellular exosome	331	25.5007704160246	6.61E − 26	GOTERM_MF_DIRECT	GO:0005515∼protein binding	233	57.2481572481572	5.48E − 07
	GOTERM_CC_DIRECT	GO:0031012∼+A1	69	5.31587057010785	2.26E − 19	GOTERM_CC_DIRECT	GO:0005737∼cytoplasm	152	37.3464373464373	1.25E − 06
	GOTERM_CC_DIRECT	GO:0005615∼extracellular space	164	12.6348228043143	1.98E − 13	GOTERM_CC_DIRECT	GO:0005654∼nucleoplasm	86	21.1302211302211	1.16E − 04
	GOTERM_BP_DIRECT	GO:0030198∼extracellular matrix organization	46	3.54391371340523	9.99E − 13	GOTERM_CC_DIRECT	GO:0016020∼membrane	70	17.1990171990172	2.74E − 04
	GOTERM_CC_DIRECT	GO:0005578∼proteinaceous extracellular matrix	54	4.16024653312788	1.67E − 12	GOTERM_CC_DIRECT	GO:0005829∼cytosol	96	23.5872235872235	4.19E − 04
	GOTERM_CC_DIRECT	GO:0005925∼focal adhesion	67	5.16178736517719	6.60E − 12	GOTERM_CC_DIRECT	GO:0070062∼extracellular exosome	83	20.3931203931203	6.83E − 04
	GOTERM_CC_DIRECT	GO:0009986∼cell surface	82	6.31741140215716	1.84E − 11	GOTERM_MF_DIRECT	GO:0004693∼cyclin-dependent protein serine/threonine kinase activity	6	1.47420147420147	7.00E − 04
	GOTERM_BP_DIRECT	GO:0007155∼cell adhesion	73	5.62403697996918	9.83E − 11	GOTERM_MF_DIRECT	GO:0030332∼cyclin binding	5	1.22850122850122	7.36E − 04
	GOTERM_CC_DIRECT	GO:0005576∼extracellular region	175	13.4822804314329	3.89E − 10	GOTERM_BP_DIRECT	GO:0048146∼positive regulation of fibroblast proliferation	7	1.71990171990172	8.99E − 04
	GOTERM_MF_DIRECT	GO:0005515∼protein binding	711	54.7765793528505	8.26E − 10	GOTERM_BP_DIRECT	GO:0000082∼G1/S transition of mitotic cell cycle	9	2.21130221130221	0.001364705455254
	GOTERM_MF_DIRECT	GO:0008201∼heparin binding	35	2.69645608628659	3.49E − 09	GOTERM_BP_DIRECT	GO:0048839∼inner ear development	6	1.47420147420147	0.00158628474829
	GOTERM_MF_DIRECT	GO:0005178∼integrin binding	27	2.08012326656394	8.57E − 09	GOTERM_BP_DIRECT	GO:0031581∼hemidesmosome assembly	4	0.982800982800982	0.001745599823436
	GOTERM_BP_DIRECT	GO:0048146∼positive regulation of fibroblast proliferation	19	1.46 E + 00	1.38E − 08	GOTERM_BP_DIRECT	GO:0051591∼response to cAMP	6	1.47420147420147	0.002664403703622
	GOTERM_BP_DIRECT	GO:0007568∼aging	33	2.54237288135593	1.37E − 07	GOTERM_BP_DIRECT	GO:0001525∼angiogenesis	13	3.19410319410319	0.002731528888927
	GOTERM_BP_DIRECT	GO:0060333∼interferon-gamma-mediated signaling pathway	20	1.54083204930662	2.89E − 07	GOTERM_CC_DIRECT	GO:0005615∼extracellular space	44	10.8108108108108	0.003130126302432
KEGG pathway	KEGG_PATHWAY	hsa05166: HTLV-I infection	49	3.77503852080123	1.54E − 08	KEGG_PATHWAY	hsa05200: pathways in cancer	22	5.4054054054054	0.001345594815917
	KEGG_PATHWAY	hsa05150: Staphylococcus aureus infection	20	1.54083204930662	1.67E − 08	KEGG_PATHWAY	hsa04151: PI3K-Akt signaling pathway	19	4.66830466830466	0.003848355864399
	KEGG_PATHWAY	hsa04510: focal adhesion	40	3.08166409861325	3.47E − 07	KEGG_PATHWAY	hsa04923: regulation of lipolysis in adipocytes	6	1.47420147420147	0.015090205294328
	KEGG_PATHWAY	hsa05323: rheumatoid arthritis	23	1.77195685670261	1.19E − 06	KEGG_PATHWAY	hsa04110: cell cycle	9	2.21130221130221	0.015736544810328
	KEGG_PATHWAY	hsa05416: viral myocarditis	18	1.38674884437596	1.41E − 06	KEGG_PATHWAY	hsa05222: small cell lung cancer	7	1.71990171990172	0.023482661953239
	KEGG_PATHWAY	hsa04514: cell adhesion molecules (CAMs)	30	2.31124807395993	2.37E − 06	KEGG_PATHWAY	hsa00010: glycolysis/gluconeogenesis	6	1.47420147420147	0.03037227765735
	KEGG_PATHWAY	hsa05310: asthma	12	0.924499229583975	1.17E − 05	KEGG_PATHWAY	hsa03320: PPAR signaling pathway	6	1.47420147420147	0.03037227765735
	KEGG_PATHWAY	hsa04110: cell cycle	26	2.00308166409861	1.49E − 05	KEGG_PATHWAY	hsa04610: complement and coagulation cascades	6	1.47420147420147	0.033914937801339
	KEGG_PATHWAY	hsa04610: complement and coagulation cascades	18	1.38674884437596	2.41E − 05	KEGG_PATHWAY	hsa05205: proteoglycans in cancer	11	2.7027027027027	0.036633631217231
	KEGG_PATHWAY	hsa04612: antigen processing and presentation	19	1.46379044684129	2.49E − 05	KEGG_PATHWAY	hsa04921: oxytocin signaling pathway	9	2.21130221130221	0.042657563729801

BP: biological process; CC: cellular component; GO: gene ontology; MF: molecular function.