Effects of Proanthocyanidins on Arsenic Methylation Metabolism and Efflux in Human Hepatocytes L-02
Figure 1
Effects of proanthocyanidins (PC) on inorganic arsenic, arsenic metabolites, and total arsenic (TAs) contents in L-02 cells exposed by arsenic trioxide (ATO). The contents of iAs3+ (a), iAs5+ (b), MMA (c), DMA (d), and TAs (e) are shown. Values are means (n=3 for each group), with standard deviations represented by vertical bars. Indicating significant difference from ATO exposure group with 24h at P<0.05. Indicating significant difference from PC (10mg/L)-treated group with 24h at P<0.05. Indicating significant difference from PC (25mg/L)-treated group with 24h at P<0.05. Indicating significant difference from ATO exposure group with 48h at P<0.05. Indicating significant difference from PC (10mg/L)-treated group with 48h at P<0.05. Indicating significant difference from PC (25mg/L)-treated group with 48h at P<0.05. iAs, inorganic arsenic; MMA, monomethylated arsenic; DMA, dimethylated arsenic.