Effects of Proanthocyanidins on Arsenic Methylation Metabolism and Efflux in Human Hepatocytes L-02

Table 3

Effects of proanthocyanidins (PC) on the changes of the difference of extracellular and intracellular concentrations of inorganic arsenic (n=3).

Group	△iAs^3+ (μg/L)		△iAs^5+ (μg/L)
	24h	48h	24h	48h
ATO (25μmol/L)	1496.72±48.06	1457.89±25.77	372.28±16.58	361.85±36.03
ATO + PC (25μmol/L + 10mg/L)	1440.92±31.28	1305.08±42.56	354.78±16.77	315.03±38.53
ATO + PC (25μmol/L + 25mg/L)	1391.13±34.46	1310.49±14.06	335.11±40.96	317.90±26.00
ATO + PC (25μmol/L + 50mg/L)	1286.91±39.73	1129.89±94.14	246.43±44.77	276.62±23.17

Note: the results were described as mean ± SD. Indicating significant difference from ATO exposure group at P<0.05; indicating significant difference from PC (10mg/L)-treated group at P<0.05; ^△indicating significant difference from PC (25mg/L)-treated group at P<0.05. △iAs, the difference of extracellular and intracellular concentrations of inorganic arsenic; ATO, arsenic trioxide.