Quantitative Proteomic Analysis Reveals the Deregulation of Nicotinamide Adenine Dinucleotide Metabolism and CD38 in Inflammatory Bowel Disease

Figure 4

CD38 mRNA expression in patients with UC and animal colitis models from GEO datasets. (a) Colon mucosa CD38 mRNA expression in NC, UCI, and UCNI patients based on GEO GDS3319 dataset. (b) Colon mucosa CD38 mRNA expression in UCI and UCNI patients based on GEO GDS2642 dataset. (c) Colon CD38 mRNA expression in DSS induced mouse colitis model at 0D, 2D, 4D, and 6D based on GEO GDS3859 dataset. (d) Colon CD38 mRNA expression in T cell transfer mouse colitis model at 0W, 4W, and 8W based on GEO GDS4363 dataset. Significance level: P < 0.05, P < 0.01, and P < 0.001. NC, normal control; CD, Crohn’s disease; UC, ulcerative colitis; UCI, ulcerative colitis inflamed; UCNI, ulcerative colitis noninflamed; D, day; W, week.

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