Effect of crude extract of C. aurantium on fractional excretion of potassium and sodium in rats treated with cisplatin.
Days of observation
Parameter
Groups
0th day
7th day
14th day
21st day
Fractional excretion of potassium
Control
3.8 ± 0.48
5.6 ± 1.4
10 ± 2.3
9.2 ± 1.6
Cisplatin
3.8 ± 0.29
17 ± 3.2
24 ± 3.5
26 ± 2.8
Cisplatin + C. aurantium (200 mg/kg)
3.6 ± 0.23
12 ± 2.0
19 ± 2.6
19 ± 2.1
Cisplatin + C. aurantium (400 mg/kg)
3.7 ± 0.48
8.3 ± 1.8
14 ± 2.3
13 ± 1.6
Fractional excretion of sodium
Control
0.28 ± 0.036
0.30 ± 0.06
0.33 ± 0.09
0.30 ± 0.05
Cisplatin
0.26 ± 0.044
0.77 ± 0.25
0.61 ± 00.16
0.69 ± 0.09
Cisplatin + C. aurantium (200 mg/kg)
0.27 ± 0.07
0.62 ± 0.22
0.49 ± 0.11
0.53 ± 0.06
Cisplatin C. aurantium (400 mg/kg)
0.32 ± 0.14
0.43 ± 0.12
0.03 ± 0.009
0.35 ± 0.05
Statistical analysis was done through one-way analysis of variance (ANOVA) trailed by Bonferroni post hoc test for all groups in respective days. The results are considered significant () if . , . Results were compared in a column with the respective control values.