| | microRNA | Study | Country | Study design | Sample | Number | Stage | Cut-off | Follow-up (months) | Result | HR(H/L) | 95%CI | p |
| | 10b | Ji, Y 2015 | China | R | Frozen | 95 | I-IV | Median | 60 | OSm | 4.71 | 1.45-8.32 | <0.001 | | 10b | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 1.09 | 0.98-1.21 | 0.12 | | 10b | Zhang, X 2016 | China | R | Frozen | 128 | I-IV | None | 80 | OSu | 3.42 | 2.08-5.62 | <0.001 | | 10b | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 1.30 | 0.53-3.2 | 0.58 | | 10b | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 1.06 | 0.97-1.15 | 0.18 | | 15b | Guan, Y 2010 | Japan | R | Frozen | 39 | I-IV | Mean | >60 | OSm | 1.87 | 0.68-5.16 | 0.227 | | 15b | Pang, C 2015 | China | R | Frozen | 76 | II-IV | None | >60 | OSu | 5.68 | 2.81-11.50 | <0.001 | | 15b | Sun, G 2015 | China | R | Frozen | 92 | I-IV | Median | >60 | OSu | 2.21 | 1.36-3.6 | 0.001 | | 15b | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 0.67 | 0.51-0.87 | 0.003 | | 15b | Zhao, H 2017 | America | R | Serum | 106 | I-IV | Median | 24 | OSu | 0.76 | 0.40-1.52 | 0.028 | | 15b | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 0.80 | 0.65-0.99 | 0.04 | | 15b | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 0.76 | 0.63-0.91 | 0.003 | | 17 | Lu, S 2012 | China | R | Tissue | 108 | I-IV | Median | >100 | OSm | 2.14 | 1.06-4.30 | 0.034 | | 17 | Sun, C 2017 | TCGA | R | Tissue | 548 | I-IV | Median | 130 | OSu | 0.6517 | 0.50-0.85 | 0.002 | | 17-5b | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 0.934 | 0.76-1.16 | 0.54 | | 17-5b | Zhao, H 2017 | America | R | Serum | 106 | I-IV | Median | 24 | OSu | 1.7 | 1.05-4.01 | 0.043 | | 17-5b | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 1.16 | 0.95-1.42 | 0.15 | | 17-5b | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 1.01 | 0.80-1.28 | 0.94 | | 17-5p | Srinivasan, S 2011 | TCGA | R | Tissue | 111 | I-IV | 60th percentile | 120 | OSm | 0.68 | 0.54-0.85 | 0.0008 | | 20a | Srinivasan, S 2011 | TCGA | R | Tissue | 111 | I-IV | 60th percentile | 120 | OSm | 0.68 | 0.55-0.84 | <0.001 | | 20a | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 0.95 | 0.79-1.14 | 0.59 | | 20a | Sun, C 2017 | TCGA | R | Tissue | 548 | I-IV | Median | 130 | OSu | 0.6708 | 0.51-0.88 | 0.005 | | 20a | Zhao, H 2017 | America | R | Serum | 106 | I-IV | Median | 24 | OSu | 1.69 | 1.06-3.79 | 0.04 | | 20a | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 1.05 | 0.87-1.27 | 0.63 | | 20a | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 0.93 | 0.80-1.08 | 0.35 | | 21 | Guan, Y 2010 | Japan | R | Frozen | 39 | I-IV | Mean | >60 | OSm | 0.57 | 0.21-1.52 | 0.264 | | 21 | Hermansen, S 2012 | Denmark | R | FFPE | 189 | I-IV | None | >60 | OSm | 1.545 | 1.002-2.381 | 0.049 | | 21 | Wu, L 2013 | China | R | Frozen | 152 | I-IV | Mean | 60 | OSm | 3.17 | 2.39-4.179 | <0.001 | | 21 | Barbano, R 2014 | TCGA | R | Tissue | 191 | I-IV | None | >110 | OSu | 1.26 | 1.06-1.48 | 0.007 | | 21 | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 0.73 | 0.58-0.91 | 0.006 | | 21 | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 0.54 | 0.37-0.80 | 0.002 | | 21 | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 0.72 | 0.56-0.92 | 0.009 | | 21 | Zhi, F 2010 | China | R | Tissue | 124 | I-IV | Median | 100 | OSm | 1.882 | 1.07-3.308 | 0.028 | | 106a | Srinivasan, S 2011 | TCGA | R | Tissue | 111 | I-IV | 60th percentile | 120 | OSm | 0.66 | 0.52-0.83 | <0.001 | | 106a | Zhao, S 2013 | China | R | FFPE | 114 | I-IV | Median | 50 | OSm | 0.504 | 0.297–0.854 | 0 .011 | | 106a | Zhao, S 2013 | China | R | FFPE | 103 | I-IV | Median | 50 | OSm | 0.452 | 0.255–0.800 | 0 .006 | | 106a | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 0.94 | 0.73-1.20 | 0.62 | | 106a | Sun, C 2017 | TCGA | R | Tissue | 548 | I-IV | Median | 130 | OSu | 0.6341 | 0.47-0.85 | 0.003 | | 106a | Zhao, H 2017 | America | R | Serum | 106 | I-IV | Median | 24 | OSu | 1.71 | 1.07-3.63 | 0.038 | | 106a | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 0.96 | 0.80-1.15 | 0.67 | | 106a | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 0.97 | 0.81-1.17 | 0.76 | | 106a | Zhi, F 2010 | China | R | Tissue | 124 | I-IV | Median | 100 | OSm | 0.6139 | 0.34-1.11 | 0.108 | | 124 | Chen, T 2015 | China | R | Frozen | 137 | I-IV | None | 60 | OSm | 2.37 | 1.24-4.528 | 0.009 | | 124 | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 1.19 | 1.06-1.33 | 0.003 | | 124 | Zhao, H 2017 | America | R | Serum | 106 | I-IV | Median | 24 | OSu | 0.65 | 0.26-1.03 | 0.062 | | 124 | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 1.33 | 1.08-1.64 | 0.007 | | 124 | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 1.23 | 1.11-1.36 | <0.001 | | 148a | Srinivasan, S 2011 | TCGA | R | Tissue | 111 | I-IV | 60th percentile | 120 | OSm | 1.21 | 1.08-1.356 | 0.001 | | 148a | Kim, J 2014 | TCGA | R | Tissue | 482 | I-IV | None | >60 | OSu | 1.19 | 1.10-1.29 | <0.001 | | 148a | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 0.9 | 0.79-1.03 | 0.13 | | 148a | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 2.44 | 0.77-7.74 | 0.13 | | 148a | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 0.99 | 0.90-1.09 | 0.85 | | 155 | Qiu, S 2013 | TCGA | R | Tissue | 480 | I-IV | 50th percentile | >100 | OSm | 0.796 | 0.646-0.982 | 0.033 | | 155 | Barbano, R 2014 | TCGA | R | Tissue | 191 | I-IV | None | >110 | OSu | 1.23 | 1.06-1.44 | 0.008 | | 155 | Sun, J 2014 | China | R | Tissue | 131 | I-IV | Mean | 80 | OSu | 2.05 | 1.35-3.12 | <0.001 | | 155 | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 0.91 | 0.77-1.07 | 0.27 | | 155 | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 0.70 | 0.18-2.73 | 0.62 | | 155 | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 0.91 | 0.77-1.07 | 0.26 | | 182 | Jiang, L 2010 | China | R | FFPE | 119 | I-IV | Median | 80 | OSm | 3.39 | 1.98-5.80 | <0.001 | | 182 | Xiao, Y 2016 | China | R | Blood | 112 | I-IV | None | 60 | OSm | 1.25 | 0.89-2.53 | 0.013 | | 182 | Zhao, H 2017 | America | R | Serum | 106 | I-IV | Median | 24 | OSu | 0.6 | 0.29-0.92 | 0.037 | | 182a | Zhao, S 2013 | China | R | FFPE | 114 | I-IV | Median | 50 | OSm | 0.974 | 0.611–1.554 | 0 .912 | | 182a | Zhao, S 2013 | China | R | FFPE | 103 | I-IV | Median | 50 | OSm | 1.032 | 0.630–1.693 | 0 .900 | | 196 | Guan, Y 2010 | Japan | R | Frozen | 39 | I-IV | Mean | >60 | OSm | 3.37 | 1.20-9.46 | 0.021 | | 196 | Lakomy, R 2011 | Czech | R | FFPE | 38 | I-IV | Median | >60 | OSu | 0.547 | 0.2776-1.0776 | 0.049 | | 196a | Zhao, S 2013 | China | R | FFPE | 114 | I-IV | Median | 50 | OSm | 2.252 | 1.321-3.841 | 0.003 | | 196a | Zhao, S 2013 | China | R | FFPE | 103 | I-IV | Median | 50 | OSm | 1.906 | 1.108-3.281 | 0.021 | | 196a | Guan, Y 2015 | China | R | Frozen | 63 | I-IV | None | >60 | OSu | 3.17 | 1.82-5.53 | 0.007 | | 200b | Srinivasan, S 2011 | TCGA | R | Tissue | 111 | I-IV | 60th percentile | 120 | OSm | 1.21 | 1.067-1.372 | 0.003 | | 200b | Liu, Q 2014 | China | R | Tissue | 73 | I-IV | None | 40 | OSu | 0.3 | 0.09-0.96 | 0.05 | | 200b | Men, D 2014 | China | R | Frozen | 266 | I-IV | Median | 60 | OSm | 2.9 | 1.166-7.21 | 0.022 | | 210 | Qiu, S 2013 | TCGA | R | Tissue | 480 | I-IV | 50th percentile | >100 | OSm | 0.749 | 0.591-0.949 | 0.017 | | 210 | Barbano, R 2014 | TCGA | R | Tissue | 191 | I-IV | None | >110 | OSu | 1.16 | 1.01-1.33 | 0.038 | | 210 | Lai, N 2014 | China | R | Frozen | 125 | I-IV | Mean | >100 | OSu | 2.3 | 1.47-3.61 | 0.0003 | | 210 | Lai, N 2015 | China | R | Serum | 126 | I-IV | Mean | >80 | OSm | 3.84 | 2.09-7.08 | <0.001 | | 210 | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 0.97 | 0.83-1.14 | 0.71 | | 210 | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 0.53 | 0.20-1.43 | 0.21 | | 210 | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 0.93 | 0.84-1.03 | 0.17 | | 221 | Srinivasan, S 2011 | TCGA | R | Tissue | 111 | I-IV | 60th percentile | 120 | OSm | 1.27 | 1.097-1.471 | 0.001 | | 221 | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 0.92 | 0.79-1.06 | 0.26 | | 221 | Li, X 2016 | China | R | Tissue | 45 | I-IV | Mean | 36 | OSu | 2.18 | 1.02-4.65 | 0.044 | | 221 | Zhang, R 2016 | China | R | Blood | 50 | I-IV | None | 50 | OSu | 2.4 | 1.42-4.05 | 0.001 | | 221 | Chen, Y 2017 | China | R | Tissue | 114 | I-IV | None | 72 | OSm | 2.039 | 1.06-3.91 | 0.032 | | 221 | Sun, C 2017 | TCGA | R | Tissue | 548 | I-IV | Median | 130 | OSu | 0.6856 | 0.53-0.88 | 0.003 | | 221 | Xue, L 2017 | China | R | Tissue | 165 | I-IV | Median | 60 | OSu | 1.656 | 1.135-2.486 | 0.009 | | 221 | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 0.80 | 0.19-3.30 | 0.77 | | 221 | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 0.88 | 0.74-1.04 | 0.14 | | 222 | Srinivasan, S 2011 | TCGA | R | Tissue | 111 | I-IV | 60th percentile | 120 | OSm | 1.26 | 1.11-1.43 | 0.0004 | | 222 | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 1.04 | 0.92-1.18 | 0.53 | | 222 | Li, X 2016 | China | R | Tissue | 45 | I-IV | Mean | 36 | OSu | 2.13 | 1.01-4.48 | 0.043 | | 222 | Zhang, R 2016 | China | R | Blood | 50 | I-IV | None | 50 | OSu | 2.81 | 1.70-4.65 | 0.0004 | | 222 | Chen, Y 2017 | China | R | Tissue | 114 | I-IV | None | 72 | OSm | 0.899 | 0.559-1.447 | 0.661 | | 222 | Sun, C 2017 | TCGA | R | Tissue | 548 | I-IV | Median | 130 | OSu | 0.5947 | 0.44-0.81 | 0.001 | | 222 | Zhao, H 2017 | America | R | Serum | 106 | I-IV | Median | 24 | OSu | 1.71 | 1.07-3.63 | 0.038 | | 222 | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 1.41 | 0.91-2.17 | 0.12 | | 222 | Chen, W 2016 | TCGA | R | Tissue | 109 | I-IV | Median | >60 | DFSu | 0.90 | 0.80-1.01 | 0.07 |
|
|
