Prognostic Significance of MicroRNAs in Glioma: A Systematic Review and Meta-Analysis

Table 2

Summary of the HR for microRNA expression in glioma.

microRNA	Survival analysis	Number of articles	Included references	HR	95%CI	P value	Heterogeneity	Total patients	Figure	Publication bias
10b	OS/DFS	3	[27–29]	1.349	0.984-1.849	0.063	89.7%, p<0.001	550	4A	0.16
15b	OS/DFS	5	[15, 16, 26, 28, 30]	1.584	1.199-2.092	0.001	74.9%, p=0.001	640	2A	0.263
17	OS/DFS	5	[20, 26, 28, 31, 32]	0.933	0.759-1.149	0.516	75.8%, p<0.001	1200	4B	0.368
20a	OS/DFS	4	[20, 26, 28, 31]	0.919	0.755-1.119	0.399	77.9%, p<0.001	1092	4C	0.925
21	OS/DFS	6	[18, 28, 30, 33–35]	1.591	1.278-1.981	<0.001	82.6%, p<0.001	1022	2B	0.536
106a	OS/DFS	6	[20, 26, 28, 31, 34, 36]	0.809	0.655-0.998	0.048	77.9%, p<0.001	1433	3A	0.177
124	OS/DFS	3	[26, 28, 37]	0.833	0.729-0.952	0.007	66.6%, p=0.018	570	3B	0.516
148a	OS/DFS	3	[28, 31, 38]	1.122	1.023-1.231	0.015	60.5%, p=0.038	920	2C	0.254
155	OS/DFS	4	[28, 33, 39, 40]	1.143	0.942-1.387	0.175	74.9%, p=0.001	1129	4D	0.586
182	OS	4	[26, 36, 41, 42]	1.206	0.709-2.051	0.489	81%, p<0.001	554	4E	0.955
196	OS	4	[30, 36, 43, 44]	1.877	1.033-3.411	0.039	77.5%, p=0.001	357	2D	0.893
200b	OS	3	[31, 45, 46]	1.113	0.451-2.744	0.816	77.5%, p=0.012	450	4F	0.923
210	OS/DFS	5	[28, 33, 40, 47, 48]	1.251	1.010-1.550	0.04	84.7%, p<0.001	1249	2E	0.181
221	OS/DFS	7	[19, 20, 28, 31, 49–51]	1.269	1.054-1.527	0.012	77.0%, p<0.001	1360	2F	0.194
222	OS/DFS	7	[19, 20, 26, 28, 31, 49, 50]	1.104	0.907-1.343	0.325	83.5%, p<0.001	1301	4G	0.765

DFS: disease free survival; HR: hazard ratio; OS: overall survival; Higgins I² statistic.