Prognostic Significance of MicroRNAs in Glioma: A Systematic Review and Meta-Analysis

Table 3

Summary of miRs with altered expression, their potential targets, and pathways entered this study.

miRNA	Expression	Potential targets	Pathways	Reference
15b	Up	cyclin D1, MMP-3, NRP	Angiogenesis, cell apoptosis, cell cycle progression, cell invasion	[52, 53]
21	Up	BTG2, PDCD4, PTEN	Cell apoptosis, invasion, migration, tumor growth	[54–56]
148a	Up	BIM, MIG6	Cell apoptosis	[38]
196	Up	HOXA7, HOXB8, HOXC8, HOXD8, IκBα	Malignant transformation, tumorigenesis,	[57–60]
210	Up	FGFRL1, HIF-1a	Angiogenesis, cell migration, cell proliferation,	[61–63]
221	Up	AKT, p27Kipl, Growth factor signaling pathways	Cell proliferation, cell apoptosis, malignant phenotype	[64, 65]
106a	Down	E2F1, TIMP-2	Cell apoptosis, cell invasion, cell proliferation,	[66]
124	Down	STAT3	T cell mediated clearance of glioma	[67]
10b	Up	RhoC, uPA	Cell invasion, cell migration	[68, 69]
17	Up or down	E2F1, TSP-1	Angiogenesis, cell growth, cell migration	[70, 71]
20a	Up	E2F1, TIMP-2	Cell invasion, cell proliferation	[72–75]
155	Up	FOXO3a, p53	Cell invasion, cell migration	[76–78]
182	Down	FOXO3, MITF-M	Cell migration, cell survival	[79]
200b	Up or down	cyclin D1, EGFR, RND3	Cell migration, epithelial-to mesenchymal transition	[80, 81]
222	Up	p27Kip1	Cell cycle progression, cell invasion, cell proliferation	[19, 65]

AKT, AKT serine/threonine kinase; BTG2, B cell translocation gene 2; E2F1, E2F transcription factor 1; EGFR, epidermal growth factor receptor; FGFRL1, fibroblast growth factor receptor-like 1; FOXO3a, forkhead box O3; HIF-1a, hypoxia-inducible factor 1a; HOX, homeobox; MIG6, mitogen-inducible gene 6; MITF-M, microphthalmia-associated transcription factor-M; MMP-3, matrix metalloproteinase-3; NRP, nitrogen regulatory protein; PDCD4, programmed cell death 4; PTEN, protein tyrosine phosphatase; RHOC, ras homolog family member C; RND3, rho family GTPase 3; STA3, signal transducers and activators of transcription; TIMP-2, tissue inhibitor of metalloproteinases-2; TSP-1, thrombospondin-1; uPA, urokinase-type plasminogen activator.