Trans-Cinnamaldehyde Inhibits IL-1β-Stimulated Inflammation in Chondrocytes by Suppressing NF-κB and p38-JNK Pathways and Exerts Chondrocyte Protective Effects in a Rat Model of Osteoarthritis

Figure 3

TCA reduces the mRNA expression of MMP-1, MMP-3, MMP-13, ADAMTS-4, and ADAMTS-5 in IL-1β-stimulated SW1353 cells. The SW1353 cells were pretreated with varying concentrations of TCA (2-20 μg/ml) for 2 h followed by IL-1β (10ng/ml) stimulation for 6 h. The mRNA was assessed by RT-qPCR. (a) MMP-1. (b) MMP-3. (c) MMP-13. (d) ADAMTS-4. (e) ADAMTS-5. P<0.05; P<0.01.

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