Trans-Cinnamaldehyde Inhibits IL-1β-Stimulated Inflammation in Chondrocytes by Suppressing NF-κB and p38-JNK Pathways and Exerts Chondrocyte Protective Effects in a Rat Model of Osteoarthritis

Figure 4

TCA suppresses NF-κB activation and IκB degradation in IL-1β-stimulated SW1353 cells. The SW1353 cells were preprocessed with varying concentrations of TCA (2-20 μg/ml) for 2 h, then stimulated with IL-1β (10 ng/ml) for 6 h. The proteins were detected by Western blot. The protein expression of IκBα (b) and p-IκBα (c) was standardized according to the respective level of GAPDH protein. Value was used to express relative changes compared with control, which was set to 1. P <0.05.

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