Trans-Cinnamaldehyde Inhibits IL-1β-Stimulated Inflammation in Chondrocytes by Suppressing NF-κB and p38-JNK Pathways and Exerts Chondrocyte Protective Effects in a Rat Model of Osteoarthritis

Figure 7

TCA exerts cartilage protective effects in MIA-induced rats after 4 weeks of intraperitoneal injection. (a) Knee joint sections were stained with Safranin O/fast green. The sections were from rats after 4 weeks administration of TCA or vehicle. Representative sections are shown. Formation of osteophytes (yellow arrow), severe disruption of meniscal tissue (yellow box), and hyperplasia of synoviocyte (red arrow) were observed in vehicle-treated MIA-induced rats. There was mild fibroid-like change in TCA-treated MIA-induced group (red box). (b) OARSI scores of articular cartilage at 4 weeks after surgery. P<0.05, NS: not statistically significant.

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