Protective Effect of the MCP-1 Gene Haplotype against Schizophrenia

Table 2

Genotype distribution and allele frequencies of MCP-1 polymorphisms in healthy controls and patients with Schizophrenia.

Genotype	Healthy controls n = 200 (%)	Patients n = 200 (%)	OR (95% CI)	value	AIC
MCP-1 -2518A/G (rs1024611)
Genotypes
AA	124 (62%)	166 (83%)
AG	69 (34.5%)	33 (16.5%)	0.35 (0.22–0.57)	0.000015
GG	7 (3.5%)	1 (0.5%)	0.10 (0.004–0.7)	0.015	536.4
Dominant (AA vs AG + GG)			0.33 (0.20–0.53)	0.0000023	536
Recessive (AA + AG vs GG)			0.13 (0.006–0.9)	0.067	553.4
HWE^a	0.48	0.22
Alleles
A	317 (79.25%)	365 (91.25%)
G	83 (20.75%)	35 (8.75%)	0.36 (0.23–0.55)	0.000001
MCP-1 -362 G/C (rs2857656)
Genotypes
GG	67 (33.5%)	46 (23%)
GC	92 (46%)	88 (44%)	1.3 (0.86–2.24)	0.17
CC	41 (20.5%)	66 (33%)	2.33 (1.36–4.03)	0.001	552.4
Dominant (GG vs GC + CC)			1.68 (1.08–2.63)	0.02	554.8
Recessive (GG + GC vs CC)			1.9 (1.21–3.01)	0.004	552
HWE^a	0.82	2.46
Alleles
G	226 (56.5%)	180 (45%)
C	174 (43.5%)	220 (55%)	1.58 (1.2–2.09)	0.001
MCP-1 int1del554-567 (rs3917887)
Genotypes
Ins/Ins	136 (68%)	154 (77%)
Ins/Del	59 (29.5%)	41 (20.5%)	0.61 (0.38–0.97)	0.03
Del/Del	5 (2.5%)	5 (2.5%)	0.88 (0.23–3.3)	0.8	553.1
Dominant (Ins/Ins vs Ins/Del + Del/Del)	—	—	0.63 (0.4–0.98)	0.04	551.4
Recessive (Ins/Ins + Ins/Del vs Del/Del)	—	—	1 (0.26–3.77)	>0.99	555.7
HWE^a	0.22	1.23
Alleles
Ins	331 (82.75%)	349 (87.25%)
Del	69 (17.25%)	51 (12.75%)	0.7 (0.47–1.03)	0.075

OR: odds ratio; CI: confidence interval; HC: healthy controls; ; HWE: Hardy–Weinberg equilibrium; ^aChi-square value AIC (Akaike information criterion) provides a means for model selection.