Role of TGF-Beta1/SMAD2/3 Pathway in Retinal Outer Deep Vascular Plexus and Photoreceptor Damage in Rat 50/10 Oxygen-Induced Retinopathy

Figure 1

Central retinal vasculatures development from D8 to D14. From D8 to D14, SVP and iDVP were present in the central region and proliferated along time. In contrast, the oDVP was not visible in D8 retina. In the retina of D10, oDVP started to grow in the central region. Afterwards, the oDVP sprouted on D12 and proliferated on D14. SVP: superficial vascular plexus (green); iDVP: inner deep vascular plexus (yellow); oDVP: outer deep vascular plexus (purple). Taken together, the timeline of the normal development of central oDVP in newborn rats was from D8 to D14. Scale bar=50 μm.