Cytotoxic and Antitumor Activity of Lactaptin in Combination with Autophagy Inducers and Inhibitors
Figure 10
RL2 in combination with CQ delays tumor development. Female CBA mice aged 8-9 weeks were used for intramuscular RLS cell transplantation. The mice were randomly divided into 4 groups (6-9 mice in group): RL2 (12 mg/kg) dissolved in saline was administered i.v. via the tail vein every 2-3 days starting on day 8 after the tumor transplantation, CQ (50 mg/kg) dissolved in saline was administered i.p. daily, RL2 in combination with CQ was administered as described above, respectively. (a) The growth rate of RLS tumors. (b) Lifespan of control and experimental mice. Error bars represent mean ± standard deviation. The statistical difference in median tumor volume between the control and the experimental groups was P<0.05. Student’s t-test was used for statistical analysis. Results are reported as the mean ± standard deviation (SD).