Cytotoxic and Antitumor Activity of Lactaptin in Combination with Autophagy Inducers and Inhibitors

Figure 3

The influence of CQ and Ku with RL2 on viability of MDA-MB-231 cells and MCF-7 cells. Detection of viability was produced by MTT assay. (a)–(c) Cytotoxic effect of CQ (0-100 μM) alone and in combination with RL2 (0.1 mg/mL) on MDA-MB-231 and MCF-7 cells. Combinatorial index (CI) is 0.77-1. (d)–(f) Cytotoxic effect of Ku (0-40 μM) alone and in combination with RL2 (0.1 mg/mL) on MDA-MB-231 and MCF-7 cells. Combinatorial index (CI) is 0.47-1. CI was calculated with CompuSyn version 1.0.