Adenosine Generated by Regulatory T Cells Induces CD8⁺ T Cell Exhaustion in Gastric Cancer through A2aR Pathway

Table 1

Frequency of FoxP3⁺ Tregs and density ratios of A2aR⁺/CD8⁺ T cells in GC tissues according to clinicopathological parameters.

Variables	n = 52	FoxP3^+ (cells/HPF)	value	A2aR^+/CD8^+ (%)	value
Gender			0.155		0.250
Male	39	18.96 ± 0.68		25.37 ± 1.07
Female	13	20.86 ± 1.08		22.66 ± 2.16
Age, years			0.152		0.266
≥60	31	20.51 ± 1.00		26.09 ± 1.68
<60	21	18.81 ± 0.81		23.91 ± 1.14
Differentiation			0.072		0.227
Low	26	18.12 ± 0.75		25.37 ± 1.46
Medium	15	20.59 ± 1.17		22.34 ± 1.54
High	11	20.98 ± 1.31		26.77 ± 2.04
Stage (TNM)			0.025		0.003
I-II	23	17.48 ± 0.81		21.61 ± 1.36
III-IV	29	20.99 ± 0.80		27.31 ± 1.31
Lymphatic metastasis			0.003		0.025
Negative	16	16.85 ± 0.97		23.17 ± 1.48
Positive	36	20.58 ± 0.70		28.12 ± 1.25
Distant metastasis			0.015		0.020
Negative	48	19.06 ± 1.12		22.72 ± 1.74
Positive	4	23.47 ± 1.52		29.38 ± 2.15
Classification			0.527		0.258
Adenocarcinoma	39	19.10 ± 0.66		23.92 ± 1.11
Mucinous adenocarcinoma	4	21.35 ± 2.44		25.93 ± 3.47
Signet-ring cell carcinoma	9	20.04 ± 1.41		28.05 ± 2.30

.