Modulation of Corneal FAK/PI3K/Akt Signaling Expression and of Metalloproteinase-2 and Metalloproteinase-9 during the Development of Herpes Simplex Keratitis

Figure 2

Expression of MMP-2 and MMP-9 protein in corneal tissue of BALB/c mice after 0, 2, 7, 14, and 28d of infection with HSV-1. The expression of MMP-2 in the epithelium and the expression of MMP-9 in the stroma showed diffuse fluorescence after 0d of infection. The fluorescence intensity of MMP-2 and MMP-9 at 2d was higher than that of 0d and 7d. The fluorescence intensity of MMP-2 and MMP-9 reached summit at 14d. After 28d of infection, expressions of MMP-2 and MMP-9 protein were weaker than that of 14d.