A Six-Gene Signature Predicts Survival of Adenocarcinoma Type of Non-Small-Cell Lung Cancer Patients: A Comprehensive Study Based on Integrated Analysis and Weighted Gene Coexpression Network

Table 3

Univariate Cox regression analysis of lightcyan module genes and overall survival.

Genes	Overall survival
	HR	CI (95% CI)	value
RRM2	1.291	1.152–1.448	<0.001
RPS6KL1	0.798	0.709–0.897	<0.001
RTL1	1.132	1.054–1.215	0.001
RXFP1	0.864	0.787–0.949	0.002
RRM1	1.438	1.121–1.845	0.004
RTCD1	1.489	1.100–2.014	0.010
RRAGB	0.706	0.537–0.929	0.013
RSPH10B2	0.909	0.842–0.981	0.014
RRM2B	0.784	0.641–0.958	0.017
RSPH9	0.901	0.826–0.983	0.019
RXFP2	0.734	0.562–0.960	0.024
RUNX1	0.798	0.645–0.988	0.038

HR, hazard ratio; CI, confidence interval. Association of the 61 genes of the lightcyan module with survival was analyzed using univariate Cox regression analysis. Presented in the table were those which showed significant association ().