The Model of Aging Acceleration Network Reveals the Correlation of Alzheimer’s Disease and Aging at System Level

Figure 6

The shortest pathways (a) enriched on the KEGG pathway of Alzheimer’s disease (p=1.2891e-05, FDR=0.0024; p=7.1372e-04, FDR=0.1328; p=3.5946e-04, FDR=0.0669), (b) enriched on the chemokine signaling pathway (p=9.9905e-04, FDR=0.1858), and (c) enriched on the GO BP term of protein dealkylation (GO:0008214, p=5.1337e-06, FDR=0.0228). The green nodes represented the aging biomarkers, the yellow nodes represented the AD biomarkers, and the blue nodes were the genes through which the shortest path passed. Genes that coincided with enriched functions were red-framed.

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(b)

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