Rapid Enkephalin Delivery Using Exosomes to Promote Neurons Recovery in Ischemic Stroke by Inhibiting Neuronal p53/Caspase-3

Figure 2

Effect of enkephalin on hippocampal neuron apoptosis induced by GLU. (a) Western blot of p53 and caspase-3 in hippocampal neurons. (b) p53 and caspase-3 gene expression detected by RT-PCR. (c) Annexin V-PI staining of hippocampal neurons and apoptosis percentage measured by flow cytometry (n=8 per group). Results are expressed as mean ± SD, P< 0.05, and ^##P< 0.01.

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