Rapid Enkephalin Delivery Using Exosomes to Promote Neurons Recovery in Ischemic Stroke by Inhibiting Neuronal p53/Caspase-3

Figure 3

Tar-exo transfer to the ischemic zone in tMCAO. Rats were treated with exosomes or tar-exo at 2 h after tMCAO. Rats’ brain sections were stained at 4 h and 12 h after vesicles treatment. Exosomes and tar-exo were stained with rhodamine (red) prior to injection, whereas Iba1 (green) was used to stain microglia. (a), (b) Representative images and quantification showing vesicles transfer and infiltration. Scale bar, 50 μm (n=10 per group). Results are expressed as mean ± SD, P< 0.01.

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