Rapid Enkephalin Delivery Using Exosomes to Promote Neurons Recovery in Ischemic Stroke by Inhibiting Neuronal p53/Caspase-3

Figure 4

Effect of tar-exo-enkephalin on neurons injury induced by tMCAO. Rats were treated with enkephalin-exo or enkephalin-tar-exo at 2 h after tMCAO. CSF was collected at 3 and 7 days after vesicles treatment. ELISA and Griess reagent kit were used to measure LDH, p53, caspase-3, and NO levels in CSF. Results are expressed as mean ± SD, ^#P< 0.05, and ^##P< 0.01.

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