Research Article

Novel Hybrid Gels Made of High and Low Molecular Weight Hyaluronic Acid Induce Proliferation and Reduce Inflammation in an Osteoarthritis In Vitro Model Based on Human Synoviocytes and Chondrocytes

Figure 5

Analysis of IL-6, GM-CSF, IL-8, INF-γ, and TNF-α levels in supernatants (pg/mL) by the Bio-Plex cytokines assay of chondrocytes treated for 48 h with H-HA or HCC 0.32% w/v with respect to H-CTRL and P-CTRL. Data shown are means ± SD. Significant differences between H-HA and HCC versus P-CTRL, H-HA versus HCC, and H-HA or HCC versus H-CTRL are indicated with asterisks p<0.05, #p<0.01.