Research Article

Novel Hybrid Gels Made of High and Low Molecular Weight Hyaluronic Acid Induce Proliferation and Reduce Inflammation in an Osteoarthritis In Vitro Model Based on Human Synoviocytes and Chondrocytes

Figure 7

mRNA expression analysis of IL-6 and IL-8 in human synoviocytes isolated from osteoarthritic synovial fluid through qRT-PCR. (a) Quantitative gene expression of IL-6 and IL-8 in primary synoviocytes after 24 h of treatment with H-HA and HCC 0.32% w/v with respect to UT-S. (b) Gene expression of IL-6 and IL-8 in synoviocytes after 48 h of treatment with H-HA and HCC 0.32% w/v with respect to UT-S. Data shown are means ± SD. Significant differences between H-HA and HCC versus UT-S and H-HA versus HCC are indicated with asterisks p<0.05, #p<0.01.

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