Expression Profile Analysis of Selenium-Related Genes in Peripheral Blood Mononuclear Cells of Patients with Keshan Disease

Table 2

Differently expressed selenium related genes in patients compared to controls.

Gene Name	Pubic ID	Function	logFC^a	-value	FDR
Up-regulated Genes
OPTN	NM_001008211	Transcription regulator	1.056	<0.001	0.002
WASF2	NM_006990	Cytoskeleton and cell movement	1.180	<0.001	0.005
PRSS8	NM_002773	Metabolism	1.260	<0.001	0.006
TNFAIP6	NM_007115	Apoptosis	1.199	<0.001	0.006
SELENBP1	NM_003944	Cell cycle	1.004	<0.001	0.006
IL1RL2	NM_003854	Interleukin	1.432	<0.001	0.013
BAG1	NM_004323	Oncogene related	0.898	<0.001	0.019
OSBP2	NM_030758	Ion channel and transport protein	1.057	<0.001	0.020
TMC5	NM_024780	Other	0.977	<0.001	0.028
SLC25A37	AY032628	Ion channel and transport protein	1.121	<0.001	0.030
FECH	NM_001012515	Metabolism	0.958	<0.001	0.039
GCLC	NM_001498	Metabolism	0.994	<0.001	0.033
LTBP3	NM_021070	Growth factor related	0.976	<0.001	0.038
ARG1	NM_000045	Metabolism	0.938	<0.001	0.046
CSF1	NM_005211	Cytokine	1.203	<0.001	0.044
BCL2L1	NM_138578	Apoptosis	1.205	<0.001	0.048
Down-regulated Genes
LEP	NM_017526	Receptor	−2.013	<0.001	<0.001
HBA2	NM_000517	Ion channel and transport protein	-−.698	<0.001	<0.001
SLC29A1	NM_004955	Ion channel and transport protein	−1.607	<0.001	<0.001
CSNK2A1	NM_177559	Signal transduction related	−1.668	<0.001	<0.001
TGFβ1	NM_015927	Growth factor related	−1.278	<0.001	0.006
RHOBTB3	NM_014899	Signal transduction related	−1.531	<0.001	0.006
ATP6V0D1	NM_004691	Ion channel and transport protein	−1.127	<0.001	0.019
SPTAN1	NM_003127	Cytoskeleton and cell movement	−1.118	<0.001	0.021
SLC3A2	NM_002394	Ion channel and transport protein	−1.092	<0.001	0.030
CAPNS1	NM_001749	Cytokine	−1.061	<0.001	0.033
COPE	NM_007263	Protein synthesis and modification	−1.048	<0.001	0.036

^aFC, Fold Change.