Arsenic Trioxide Suppresses Tumor Growth through Antiangiogenesis via Notch Signaling Blockade in Small-Cell Lung Cancer

<p>The effect of As<sub>2</sub>O<sub>3</sub> treatment on the regulation of the expression of the Notch pathway-related factors in HUVECs. (a) Western blot analysis to reveal the expression of Dll4, Notch1, and Hes1 proteins in the HUVECs transfected with Dll4 overexpression lentiviruses or NC lentiviruses with or without As<sub>2</sub>O<sub>3</sub> treatment. (b) The expression of Dll4, Notch1, and Hes1 proteins in the HUVECs transfected with Notch1 siRNA lentiviruses or NC lentiviruses with or without As<sub>2</sub>O<sub>3</sub> treatment.</p>

BioMed Research International

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Figure 5

Figure 5: Arsenic Trioxide Suppresses Tumor Growth through Antiangiogenesis via Notch Signaling Blockade in Small-Cell Lung Cancer 