Oxaliplatin Treatment Alters Systemic Immune Responses

Figure 5

Effects of oxaliplatin on inflammation-associated genes within the spleen. RT² profiler arrays were used to determine changes in expression of inflammation-associated genes. Oxaliplatin treatment resulted in upregulation of Csf1 and downregulation of Csf2 (a). Oxaliplatin treatment caused the upregulation of Ccr2 and downregulation of Ccr9, Ccl5 and Ccl22 gene expression (b). Oxaliplatin treatment downregulated mRNA expression levels of Aicda, Bcl2l1 and CTLA-4 (c).

(a)

(b)

(c)