A Genetic Variant in GPR126 Causing a Decreased Inclusion of Exon 6 Is Associated with Cartilage Development in Adolescent Idiopathic Scoliosis Population

Table 2

The allele and genotype frequencies of GPR126 gene polymorphisms in patients with AIS and controls.

SNP	group	Genotype frequency				Allele frequency
		AA	AG	GG	p	A	G	OR(95%CI)	p
rs41289839	AIS	7 (0.053)	64 (0.49)	60 (0.46)	1.55 × 10^−3	78 (0.30)	184 (0.70)	1.86 (1.24-2.80)	2.68 × 10^−3
A/G	control	6 (0.045)	37 (0.28)	89 (0.67)		49 (0.19)	215 (0.81)
rs6570507	AIS	36 (0.28)	53 (0.40)	42 (0.32)	4.05 × 10^−3	125 (0.48)	137 (0.52)	1.89 (1.33-2.69)	4.02 × 10^−4
A/G	control	17 (0.13)	52 (0.39)	63 (0.48)		86 (0.33)	178 (0.67)

Linkage disequilibrium tests: D’ = 0.984, r² = 0.461