Jiedu Granule Combined with Transcatheter Arterial Chemoembolization and Gamma Knife Radiosurgery in Treating Hepatocellular Carcinoma with Portal Vein Tumor Thrombus
Table 2
Main procedure-related laboratory adverse events by CTCAE grades in both groups.
CTCAE
Group
Pre-procedure
3 months post-procedure
P value
P value#
All grades
P value
Grade≥3
P value
All grades
P value
Grade≥3
P value
Leukocytopenia
TACE-GKR (n=94)
12(12.77)
0.448
0
1
16(17.02)
0.373
3(3.19)
0.721
0.539
0.246
Jiedu plus TACE-GKR (n=96)
8(8.33)
0
11(11.46)
5(5.21)
0.628
0.059
HB
TACE-GKR (n=94)
11(11.70)
0.775
0
1
9(9.58)
0.964
1(1.06)
0.495
0.813
0.301
Jiedu plus TACE-GKR (n=96)
9(9.38)
0
8(8.33)
0(0.00)
0.998
1
Thrombocytopenia
TACE-GKR (n=94)
10(10.64)
0.998
0
1
19(20.21)
0.943
3(3.19)
0.998
0.106
0.246
Jiedu plus TACE-GKR (n=96)
10(10.42)
0
18(18.75)
4(4.17)
0.152
0.121
Hypoalbumin
TACE-GKR (n=94)
12(12.77)
0.780
0
1
17(18.09)
0.978
0(0.00)
1
0.419
1
Jiedu plus TACE-GKR (n=96)
10(10.42)
0
14(14.58)
0(0.00)
0.513
1
ALT/AST↑
TACE-GKR (n=94)
37(39.36)
0.680
0
1
54(57.45)
0.551
14(14.89)
0.742
0.019
0.009
Jiedu plus TACE-GKR (n=96)
34(35.42)
0
50(52.08)
17(17.71)
0.029
<0.001
TB↑
TACE-GKR (n=94)
23(24.47)
0.806
0
1
40(42.55)
0.757
4(4.26)
0.719
0.013
0.121
Jiedu plus TACE-GKR (n=96)
26(27.08)
0
44(45.83)
3(3.13)
0.011
0.246
GGT↑
TACE-GKR (n=94)
49(52.13)
0.671
0
1
55(58.51)
0.790
18(19.15)
0.529
0.463
<0.001
Jiedu plus TACE-GKR (n=96)
54(56.25)
0
59(61.46)
23(23.96)
0.558
<0.001
Creatinine
TACE-GKR (n=94)
0(0.00)
0.497
0
1
3(3.19)
0.759
1(1.06)
0.495
0.246
0.998
Jiedu plus TACE-GKR (n=96)
2(2.08)
0
4(4.17)
0(0.00)
0.683
1
INR
TACE-GKR (n=94)
7(7.45)
0.998
0
1
13(13.83)
0.940
0(0.00)
0.497
0.237
1
Jiedu plus TACE-GKR (n=96)
8(8.33)
0
14(14.58)
2(2.08)
0.257
0.497
: intragroup differences in all grades laboratory adverse events between baseline and month 3 were analysed with Exact McNemar’s test; p<0.05 was considered statistically significant. #: intragroup differences in grade≥ laboratory adverse events between baseline and month 3 were also analysed with Exact McNemar’s test. TB: total bilirubin; ALT: alanine transaminase; AST: aspartate transaminase; INR: international normalized ratio; GGT: gamma-glutamyl transpeptidase; CTCAE: National Cancer Institute Common Terminology Criteria for Adverse Events; GKR: gamma knife radiosurgery; TACE: transarterial chemoembolization.
