Association between Herpes Zoster and Osteoporosis: A Nested Case-Control Study Using a National Sample Cohort
Table 3
Subgroup analysis of crude and adjusted odd ratios (95% confidence interval) of osteoporosis and herpes zoster according to age and sex.
Characteristics
Herpes zoster
Crude†
P-value
Adjusted†‡
P-value
Age < 65 years, men (n = 5,620)
Osteoporosis
1.39 (1.06-1.81)
0.016
1.34 (1.01-1.78)
0.043
Control
1.00
1.00
Age < 65 years, women (n = 70,018)
Osteoporosis
1.29 (1.20-1.39)
<0.001
1.20 (1.12-1.29)
<0.001
Control
1.00
1.00
Age ≥ 65 years, men (n = 13,860)
Osteoporosis
1.34 (1.18-1.52)
<0.001
1.19 (1.04-1.36)
0.011
Control
1.00
1.00
Age ≥ 65 years, women (n = 47,486)
Osteoporosis
1.25 (1.14-1.38)
<0.001
1.09 (0.99-1.21)
0.093
Control
1.00
1.00
Conditional logistic regression analyses. Significance at P < 0.05 † Stratified based on age, income, and region of residence. ‡ Adjusted model for the Charlson Comorbidity Index score and steroids used.
