Xin-Ji-Er-Kang Alleviates Myocardial Infarction-Induced Cardiovascular Remodeling in Rats by Inhibiting Endothelial Dysfunction
Table 4
Effects of XJEK on thoracic aorta remodeling in MI rats.
Group
Time
TAA(103um2)
LA(103um2)
CSA(103um2)
AR(um)
LR(um)
MT(um)
Control
0wk
376.57±11.65
285.52±10.55
91.06±4.23
345.97±5.40
301.15±5.62
44.81±2.01
Sham
2wk
396.45±14.85
308.04±13.86
88.41±7.81
354.78±6.73
312.56±7.11
42.23±1.27
MI
460.73±24.59
334.60±17.95
126.13±7.64
381.95±10.47
325.49±8.99
56.47±2.21
MI+XJEK
424.75±20.05#
323.49±17.03#
101.26±4.21###
366.73±8.70#
319.84±8.45
46.89±1.33###
MI+Fosinopril
358.72±11.05##
267.88±8.64#
90.84±3.28##
337.68±5.13##
291.78±4.65#
45.89±1.23##
Sham
4wk
428.24±16.97
327.46±14.02
100.78±3.23
368.68±7.45
322.32±7.04
46.36±0.72
MI
467.81±24.91
332.99±16.64
134.82±8.66
384.77±9.80
324.71±7.86
60.05±2.24
MI+XJEK
348.88±19.14##
257.17±18.13##
91.71±1.80###
331.76±9.48###
283.98±10.52#
47.78±1.28###
MI+Fosinopril
415.35±17.90
311.45±16.26
103.90±4.08##
362.73±7.99
313.69±8.59
49.04±1.99##
Sham
6wk
447.41±13.95
333.27±16.07
113.43±4.43
376.25±5.61
323.73±7.51
51.81±2.56
MI
570.04±41.35
421.32±24.98
148.72±17.33
423.50±15.27
364.79±10.72
58.70±5.08
MI+XJEK
457.76±17.77
341.10±19.27
116.66±4.35#
381.28±7.44
328.70±9.42
52.58±2.71#
MI+Fosinopril
409.38±23.97#
303.47±19.51#
105.91±6.26##
359.23±10.63#
308.87±10.37
50.37±2.30###
TAA: area of total aorta; LA: area of lumen; CSA: cross-sectional area; AR: aorta radius; LR: luminal radius; MT: media thickness. (mean±SEM, n=8~10). Data are represented as mean±SEM (n=8~10). <0.05, <0.01, and <0.001versus sham group, #P<0.05, ##P<0.01, and ###P<0.001 versus MI group.
