Silymarin Ameliorates Acrylamide-Induced Hyperlipidemic Cardiomyopathy in Male Rats

Table 1

Effect of silymarin on cardiac lipid peroxidation production and antioxidant enzyme activities in rats treated with acrylamide.

Experimental groups	MDA nmol/g tissue	SOD U/mg protein	CAT U/mg protein	GPxm U/mg protein
Control	22.40^a ± 0.81	66.60^a   1.03	44.80^a ± 1.50	61.60^a ± 1.03
AA	62.40^c ± 1.17	26.40^c ± 0.75	17.20^c ± 1.02	22.60^c ± 0.68
SIL	24.18^a ± 0.22	64.40^a ± 1.36	45.80^a ± 1.16	61.40^a ± 1.17
AA+SIL	32.80^b ± 1.07	46.60^b ± 0.68	29.60^b ± 1.03	33.0^b ± 1.18
One-way ANOVA F (p)	466.00 (<0.001^*)	354.46 (<0.001^*)	130.75 (<0.001^*)	370.65 (<0.001^*)

Data are expressed as the mean ± SE of five rats/group. Means within the same column with different superscript letters are significant. *: Statistically significant at . MDA: malondialdehyde, SOD: superoxide dismutase, CAT: catalase, GPx: glutathione peroxidase.