LC-MS/MS Analysis and Hepatoprotective Activity of Artichoke (Cynara scolymus L.) Leaves Extract against High Fat Diet-Induced Obesity in Rats

Table 4

Effect of treatment with C. scolymus leaves extract on serum lipid profile.

Groups	Cont	HFD	HFD+ EEA; (200mg/kg / bw)	HFD+EEA (400mg/kg/bw)	HFD+ATOR
TG (mmol/L)	1.00 ± 0.29	2.50±0.40	1.13 ± 0.20^###	0.8± 0.42^###	1.00 ± 0.29^###
T-Ch (mmol/L)	1.37 ± 0.12	3.50±0.55	1.60 ± 0.15^###	1.70 ± 0.15^###	1.62 ± 0.08^###
LDL- c (mmol/L)	0.60 ± 0.19	1.80±0.07	1.30± 0.35^###	0.80 ± 0.01^###	0.45 ± 0.40^###
HDL-c (mmol/L)	1.44 ± 0.33	0.50±0.10	0.80 ± 0.33^###	1.19± 0.07^###¥	0.76 ± 0.08^###
AIP	0.95 ± 0.17	6.88±0.14	2.00 ± 0.12^###	1.48 ±0.19^###¥¥	2.13 ± 0.20^###
CRI-I	0.951	7	2	1.42	2.13

HFD groups were orally administered with ethanol extract (EEA) from leaves of C. scolymus and atorvastatin (ATOR) at the doses mentioned earlier for 60 days. Values are given as means ± SD (n = 6). p ≤ 0.001 was considered significant compared to control groups; ^### p ≤ 0.001 was considered significant compared to HFD groups; ^¥p ≤ 0.05 and ^¥¥ p ≤ 0.01 were considered significant compared to HFD groups treated with ATOR.