LC-MS/MS Analysis and Hepatoprotective Activity of Artichoke (Cynara scolymus L.) Leaves Extract against High Fat Diet-Induced Obesity in Rats

Table 6

Effect of treatment with C. scolymus leaves extracts on hematological parameters.

Groups	Cont	HFD	HFD+EEA (200mg/kg/bw)	HFD+EEA (400mg/kg/bw)	HFD+ATOR
GR (×10^6)	6.96 ± 2.37	9.13 ± 0.09	8.91 ± 0.04^¥¥	9.00 ± 0.07^#¥¥¥	8.48 ± 0.04^###
Hb (g/dL)	12.55 ± 0.91	15.15± 0.91	14.85± 0.63	15.00 ± 0.21	14.80 ± 0.14
HCT(fL)	36.25± 0.96	44.35 ± 1.90	43.45 ± 1.90	38.55± 0.35^#¥¥¥	35.75 ± 0.07^#
VGM(fL)	50.55 ± 0.63	54.9±3.53	48.75 ± 2.61	50.9 ± 0.00	50.55 ± 0.63
TCMH (g/dL)	13.45± 4.73	33.7± 0.15	16.65 ± 0.91^##	16.75 ± 0.07^###¥¥¥	17.45 ± 0.07^##
MCHC (g/dL)	31.6± 1.97	33.7± 1.27	30.2 ± 0.00	32.85 ± 0.21	32.85 ± 0.21
GB (×10^3 /uL)	6.82 ± 2.06	17.45 ± 2.04	10.41 ± 2.06^#	11.2 ±1.12^#	9.46 ±1.08^##
PLT (×10^3/uL)	859 ± 9.23	1260 ± 9.34	839.5± 8.45^##	914.5± 11.87^##	879 ± 8.21^##

HFD groups were orally administered with ethanol extract (EEA) from leaves of C. scolymus and atorvastatin (ATOR) at the doses mentioned earlier for 60 days. Values are given as means ± SD (n = 6). p ≤ 0.01 and p ≤ 0.001 were considered significant compared to control groups; ^# p ≤ 0.05, ^## p ≤ 0.01, and ^### p ≤ 0.001 were considered significant compared to HFD groups; ^¥¥ p ≤ 0.01 and ^¥¥¥ p ≤ 0.001 were considered significant compared to HFD groups treated with ATOR.