Icaritin: A Novel Natural Candidate for Hematological Malignancies Therapy

Figure 1

Icaritin induced apoptosis through multiple and differential signaling pathways. Icaritin induces apoptosis by inhibiting PI3K-AKT pathway in AML and CML cells; JAK-STAT pathway in MM, CML, and NKTL cells; and MAPK/ERK pathway in AML and CML cells, while activating MAPK/JNK in CML and MM.