In Vivo, Proteomic, and In Silico Investigation of Sapodilla for Therapeutic Potential in Gastrointestinal Disorders

Figure 4

Gross-appearance of gastric mucosa in rats: (a) pretreated with saline, 10 mL/kg, severe injuries are seen, as ethanol (1 mL/100 g) produced excessive hemorrhagic necrosis of gastric mucosa pretreated with Manilkara zapota extracts: (b–d) chloroform (Mz.CHCl₃), (e–g) aqueous (Mz.Aq) at doses of 50, 100, and 300 mg/kg, respectively, and (h) pretreated with omeprazole (20 mg/kg). The injuries were reduced with the increase of Mz.CHCl₃ and Mz.Aq doses and omeprazole compared with ulcer control. At 300 mg/kg, Mz.CHCl₃ and Mz.Aq showed most efficacious gastroprotective action.

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