In Vivo, Proteomic, and In Silico Investigation of Sapodilla for Therapeutic Potential in Gastrointestinal Disorders

Table 1

Effect of Manilkara zapota extracts: chloroform (Mz.CHCl₃), aqueous (Mz.Aq), and loperamide against castor oil-induced diarrhea (10 mL/kg) in mice.

Treatment	No. of mice (out of 5) with diarrhea	Protection (%)
Saline (10 mL/kg) + castor oil	5/5	0
Mz.CHCl3 (50 mg/kg) + castor oil	2/5	60
Mz.CHCl3 (100 mg/kg) + castor oil	1/5	80
Mz.CHCl3 (300 mg/kg) + castor oil	0/5	100
Mz. Aq (50 mg/kg) + castor oil	4/5	20
Mz.Aq (100 mg/kg) + castor oil	3/5	40
Mz. Aq (300 mg/kg) + castor oil	2/5	60
Loperamide (10 mg/kg) + castor oil	0/5	100

and versus saline + castor oil-treated group (Χ²-test).