Research Article
In Vivo, Proteomic, and In Silico Investigation of Sapodilla for Therapeutic Potential in Gastrointestinal Disorders
Table 2
Effect of Manilkara zapota extracts: chloroform (Mz.CHCl3), aqueous (Mz.Aq), and atropine on charcoal meal transit time in rats.
| | Doses (mg/kg, p.o.) | Mean length of intestine (cm) | Distance moved by charcoal (cm) | % intestinal transient | % inhibition |
| | Saline (10 mL/kg) | 92.6 ± 1.6 | 90 ± 1.3 | 97.1 | — | | Mz.CHCl3 (50 mg/kg) | 87.4 ± 1.3 | 76.6 ± 1.9 | 87.64 | 9.74 | | Mz.CHCl3 (100 mg/kg) | 90.8 ± 0.8 | 70.6 ± 0.8 | 77.75 | 19.92 | | Mz.CHCl3 (300 mg/kg) | 84.4 ± 0.5 | 59.8 ± 0.3 | 70.85 | 27.03 | | Mz.Aq (50 mg/kg) | 73.6 ± 0.9 | 86.6 ± 0.2 | 84.98 | 12.48 | | Mz.Aq (100 mg/kg) | 74.2 ± 0.5 | 57 ± 0.7 | 76.81 | 20.89 | | Mz.Aq (300 mg/kg) | 77 ± 0.7 | 55.4 ± 0.9 | 71.94 | 25.91 | | Atropine (0.1 mg/kg, i.p.) | 90.8 ± 0.9 | 16.4 ± 0.6 | 18.06 | 81.40 |
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, , and compared to control saline group. One-way analysis of variance followed by Tukey’s post hoc test, n = 5. |
