In Vivo, Proteomic, and In Silico Investigation of Sapodilla for Therapeutic Potential in Gastrointestinal Disorders

Table 3

Protective effect of Manilkara zapota extracts: chloroform (Mz.CHCl₃), aqueous (Mz.Aq), and omeprazole against ethanol (1 mL/100 g) induced gastric ulcers in rats.

Treatment	Ulcer index	% inhibition
Saline 10 mL/kg + ethanol	10.0 ± 0.0	—
Mz.CHCl3 (50 mg/kg) + ethanol	8.0 ± 0.31	20
Mz.CHCl3 (100 mg/kg) + ethanol	4.2 ± 0.2	58
Mz.CHCl3 (300 mg/kg) + ethanol	2.4 ± 0.44	76
Mz.Aq (50 mg/kg) + ethanol	6.2 ± 0.3	38
Mz.Aq (100 mg/kg) + ethanol	4.4 ± 0.14	56
Mz.Aq (300 mg/kg) + ethanol	2.4 ± 0.24	76
Omeprazole (20 mg/kg) + ethanol	1.4 ± 0.24	86

, , and compared to control saline group. One-way analysis of variance, followed by Tukey’s post hoc test, n = 5.